( 2020.1.8 Talk ) Advancing Precision Medicine and Precision Health with CMOS-enabled Continuous Monitoring of Molecules, Cells, and Beyond
( 2020.1.8 Talk ) Advancing Precision Medicine and Precision Health with CMOS-enabled Continuous Monitoring of Molecules, Cells, and Beyond Speaker : Dr. Jun-Chau Chien 簡俊超博士 Staff Research Engineer, Stanford University, CA Time : January 8, 2020 (Wednesday 10:00-11:30AM Venue：R108, 1F Engineering Building 4, NCTU 交通大學工程四館一樓108室(知新廳) Language： English
Abstract : Continuous monitoring of specific biomarkers at real time, as opposed to the current standard end-point assay, introduces a new dimension in medicine and healthcare by offering longitudinal information. Such a scheme enables faster and evidence-based decision making in medical treatments as well as early disease detection to improve quality-of-life. In this talk, I will present my research on various biomedical systems for continuous monitoring at different levels with emerging applications including in vivo drug monitoring for personalized pharmacokinetics characterization and biophysical-based circulating tumor cells quantification. In particular, my research harvests the power of CMOS integrated circuits, applied physics, and advanced biotechnology to address biosensing requirement on sensitivity, specificity, throughput, multiplexing, device miniaturization, and system scaling. I will focus on four systems: (1) an electrochemical-sensing implant with wireless powering and telemetry for in vivo molecular monitoring using reagentless structure-switching aptamers; (2) a cytometry-on-CMOS system exploiting injection-locking mechanism for large-scale single-cell dielectric spectroscopy study at microwave frequencies; (3) a frequency-multiplexed neural-recording architecture with distributed “oscillatrodes'” for ultra-high-density neural probe; and (4) an low-power heart-rate sensor employing new sensing physics. Last, I will discuss my collaborative works on emerging medical imaging systems as well as my current and future research.
Bio: Jun-Chau Chien received the B.S. and M.S. degrees from National Taiwan University in 2004 and 2006, and Ph.D. degree from University of California, Berkeley, in 2015. After 2-year postdoctoral training, he is now a Staff Research Engineer at Electrical Engineering Department, Stanford University. He also held industrial positions at Xilinx, InvenSense, and HMicro in 2012, 2015, and 2017, respectively. His research focuses on CMOS bioelectronics, biosensors and analytical biochemistry, high-frequency on-chip metrology, and high-performance clocking systems. He was the recipient of the 2019 CICC Outstanding Regular Paper Award, the 2014 Microwave Theory and Techniques Society (MTT-S) Graduate Fellowship for Medical Applications, the 2014 Solid-State Circuit Society (SSCS) Predoctoral Achievement Award, the 2013–2014 Outstanding Graduate Student Instructor Award of the University of California at Berkeley, the 2014 Analog Devices Outstanding Design Award, the 2008 Berkeley Wireless Research Center Fellowship, the 2007 International Solid-State Circuits Conference (ISSCC) Silk Road Award, and the 2006 Outstanding Research Award and Annual Best Thesis Award of the Graduate Institute of Electronics Engineering, National Taiwan University, Taipei, Taiwan. He was a co-recipient of the 2010 ISSCC Jack Kilby Award for Outstanding Student Paper for his work on a 90 GHz pulser with 30 GHz of bandwidth for medical imaging.